LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin

PA Cowin; J George; S Fereday; E Loehrer; P Van Loo; C Cullinane; D Etemadmoghadam; S Ftouni; L Galletta; MS Anglesio; J Hendley; L Bowes; KE Sheppard; EL Christie; RB Pearson; PR Harnett; V Heinzelmann-Schwarz; M Friedlander; O McNally; M Quinn; P Campbell; A DeFazio; DDL Bowtell

Journal article

LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin

PA Cowin, J George, S Fereday, E Loehrer, P Van Loo, C Cullinane, D Etemadmoghadam, S Ftouni, L Galletta, MS Anglesio, J Hendley, L Bowes, KE Sheppard, EL Christie, RB Pearson, PR Harnett, V Heinzelmann-Schwarz, M Friedlander, O McNally, M Quinn Show all

Cancer Research | Published : 2012

DOI: 10.1158/0008-5472.CAN-12-0203

Abstract

High-grade serous cancer (HGSC), the most common subtype of ovarian cancer, often becomes resistant to chemotherapy, leading to poor patient outcomes. Intratumoral heterogeneity occurs in nearly all solid cancers, including ovarian cancer, contributing to the development of resistance mechanisms. In this study, we examined the spatial and temporal genomic variation in HGSC using high-resolution single-nucleotide polymorphism arrays. Multiple metastatic lesions from individual patients were analyzed along with 22 paired pretreatment and posttreatment samples. We documented regions of differential DNA copy number between multiple tumor biopsies that correlated with altered expression of genes ..

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University of Melbourne Researchers

Julie Fereday Author

Karen Sheppard Author

Richard Pearson Author

Orla McNally Author

Related Projects (3)

AUSTRALIAN OVARIAN CANCER STUDY (AOCS): A MULTIDISCIPLINARY OVARIAN CANCER RESOURCE FOR THE GENOMICS ERA

Ovarian cancer is relatively uncommon and is histologically very diverse, making it difficult to analyse ovarian cancer at a molecular level..

Australian Biospecimen Network-Oncology

Availability of ethically consented, clinically annotated human cancer tissue is a key determinant of the international competitiveness of A..

AUSTRALASIAN BIOSPECIMEN NETWORK-ONCOLOGY

Grants

Awarded by U.S. Army Medical Research and Materiel Command

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC

Awarded by Worldwide Cancer Research

Funding Acknowledgements

This work has been supported by an Association for International Cancer Research (AICR) grant (P. A. Cowin, D. D. L. Bowtell). AOCS was supported by the U.S. Army Medical Research and Materiel Command under DAMD17-01-1-0729, the National Health and Medical Research Council of Australia (NHMRC, 400281 & 400413), Cancer Council Victoria, Cancer Council Queensland, Cancer Council New South Wales, Cancer Council South Australia, The Cancer Foundation of Western Australia and Cancer Council Tasmania. The Australasian Biospecimens Network-Oncology was funded by NHMRC (310670 & 628903). P. V. Loo is a postdoctoral researcher of the Research Foundation-Flanders (FWO).